Description

Hepatocyte growth factor receptor (MET). Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.


Clinical trials

NCT03060356 - Breast Cancer, Melanoma
NCT03638206 - Colorectal Cancer, Esophagus Cancer, Renal Carcinoma, Hepatoma, Lung Cancer, Mesothelioma, Ovarian Cancer, Pancreatic Cancer, Melanoma
NCT03672305 - Hepatoma


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene MET.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.